DNA Genomic Testing

DNA-Life Tests : DNA Health

DNA-Life genomic panels test for gene variations associated with metabolic and biological processes including lipid metabolism, B vitamins & methylation, metabolism, detoxification and inflammation.  Results are presented in user-friendly reports.

 

The DNA Health test is designed to optimise well-being and health by personalising lifestyle and dietary choices or nutritional genomics, and, where necessary, using supplements tailored to offset any particular nutritional deficit based on specific gene variants.

Clinical Value

  • Highlights specific metabolic pathways that may require extra support
  • Provides recommendations that involve optimisation of quantities of certain nutrients, vitamins and minerals
  • Suggests whether an individual is better able to reduce their cholesterol levels through diet, as opposed to through medication
  • Provides an indication of the degree of susceptibility to the harmful effects of carcinogens ingested in the diet


The DNA Health Test Report provides: 

  • The level of impact of any genetic variants identified
  • An explanation of their impact on health
  • Appropriate nutritional and lifestyle recommendations


The results are divided into sections of key metabolic function, so that genetic weaknesses and strengths within a functional area can be easily identified. 

 

The DNA-Health panel provides an excellent overview, via a single self-collected buccal swab (cheek swab).  The following analytes are measured:


Lipid Metabolism

LPL:  Removes lipids from the circulation by hydrolysing triglycerides into free fatty acids.
CETP:  Plays a key role in the metabolism of HDL and mediates the exchange of lipids between lipoproteins.
APOC3:  Plays an important role in cholesterol metabolism.
APOE:  Is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Affects antioxidant requirement.

B Vitamins/Methylation

MTHFR:  Directs folate from the diet either to DNA synthesis or homocysteine re-methylation.
MTR:  Catalyses the re-methylation of homocysteine to methionine.
COMT:  Catalyses the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine.
MTRR:  Catalyses methylcobalamin, which is essential for maintaining adequate intracellular pools of methionine. It is also responsible for maintaining homocysteine concentrations at non-toxic levels.
CBS:  Catalyses the conversion of homocysteine to cystathionine and is directly involved in the removal of homocysteine from the methionine cycle.

Detoxification

CYP1A1:  The cytochrome P450 enzyme converts environmental pro-carcinogens to reactive intermediates, which are carcinogenic.
GSTM1:  Influences Phase II detoxification. It is responsible for the removal of xenobiotics, carcinogens, and products of oxidative stress.
GSTP1:  Influences the metabolism of many carcinogenic compounds.
GSTT1:  A member of a super family of proteins that catalyses the conjugation of reduced glutathione.
NQO1:  Quinone Reductase is primarily involved in the detoxification of potentially mutagenic and carcinogenic quinones derived from tobacco smoke, diet and oestrogen metabolism.

Inflammation

IL-6:  Plays a crucial role in inflammation by regulating the expression of C reactive protein (CRP).
TNF-A:  TNFa is a pro-inflammatory cytokine, secreted by both macrophages and adipocytes, which has been shown to alter whole body glucose homeostasis, and has been implicated in the development of obesity, obesity-related insulin resistance and dyslipidemia.

Food Responsiveness and Sensitivity

MCM6:  Associated with adult hypolactasia.
FADS1:  Influences blood fat concentrations by affecting desaturase enzyme efficiency.
CYP1A2:  This detoxification enzyme influences the ability to metabolise caffeine.
ACE & AGT:  Part of the renin-angiotensin system and response to salt.

Iron Overload

HFE:  Regulates iron absorption by regulating the interaction of the transferring receptor with transferrin. Hereditary haemochromatosis results from defects in the HFE gene.

Oxidative Stress

eNOS:  Influences vascular tone and peripheral vascular resistance. It also has vaso-protective effects by suppressing platelet aggregation, leukocyte adhesion and smooth muscle cell proliferation.
MnSOD/SOD2:  Has vital anti-oxidant activity within the cell, especially within the mitochondria.  It destroys the radicals that are normally produced within cells.

Bone Health

VDR:  Has a profound influence on bone density.
COL1A1:  Influences the ratio of collagen-alpha chains produced by bone cells, affecting bone mineralisation of bone and bone strength.

Insulin Sensitivity

PPARG:  Involved in adipocyte differentiation. It is a transcription factor activated by fatty acids, and is also involved in the regulation of glucose and lipid metabolism.
TCF7L2:  Influences blood glucose homeostasis – both insulin secretion and resistance.
FTO:  Influences susceptibility to obesity and risk for type 2 diabetes.
SLC2A2:  Facilitates glucose induced insulin secretion and is involved in food intake and regulation.

 

It is adviseable to include the DNA-Health test as an overview as specified above. Additional DNA-Life tests can be run alongide DNA-Health on the same sample. Discounts may be available for certain combinations of the DNA-Life tests listed below:

  • DNA Health
  • DNA Mind
  • DNA Diet
  • DNA Skin
  • DNA Oestrogen
  • DNA Sport

 

Practical Information

 

Test Type: Gene, health, nutritional genomics and metabolism

 

Sample required: Buccal swab

Average processing time: 18-21 days

 

Test Fees (exclude shipping)

 

DNA-Life Tests can be run individually or in combination with other DNA-Life tests. Available DNA-Life Tests below:

  • DNA Health: £199
  • DNA Mind: £149
  • DNA Diet: £149
  • DNA Skin: £149
  • DNA Oestrogen: £149
  • DNA Sport: £149

Discounts apply for certain combinations, please enquire.

 

Consultations with DNA-Life Certified Practitioners

It is advisable to discuss implications of test results with experienced practitioner. Consultations can be held in person or by telephone, Facetime or Skype and are not included in the test fees.

 

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